W.M.Frischi
EXPERIMENTAL STUDIES ON MICROENCAPSULATION OF PANCREATIC ISLETS FOR TRANSPLANTAION IN DIABETES MELLITUS


Citation from the Preface:

"Patients with type 1 diabetes mellitus suffer from insulin deficiency, which is due to autoimmune destruction of the insulin-secreting Betacells in the islets of Langerhans. Since insulin can be chemically extracted from pancreatic islets, diabetes has become a treatable disease, and patients are no longer exposed to the risk of death from acute ketoacidosis. Insulin can be easily administered exogenously, and adjusted to the individual needs of the patient. Howewer, over the past decades it has gradually become clear that long-term patient survival is often associated with severe, and sometimes fatal, late complications.


During the early eighties, F. LIM of the Virginia Commonwealth University ( Richmond ,USA), and A.M. SUN of the University of Toronto ( Canada), proposed an entirely new method for the prevention of graft rejection of isolated pancreatic islets. They encapsulated islets individually within a semipermeable membrane which acts as an immunological barrier between host and donor tissue. As such, transplanted islets are immunoisolated, and protected from immune rejection without the use of immunosuppression. Several subsequent  studies of the group of A.M. SUN of Connaught Research Institute ( Toronto Canada) have shown that immunoisolation with semipermeable membranes prevents immune rejection of allogenic and even xenogenic transplanted islets in rats. In paricular the use of xenogenic donor tissue would give us the opprotunity, in view of eventual clinical application, for the use of porcine of bovine islets which, as such , should solve the problem of donor shortage to be expected."


ISBN 90-9006869-4

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